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Mass effect 3 nude8/30/2023 Several genes were identified as potential functional drivers, which were significantly enriched in the GRB7-mediated RTK pathway. Here, we performed genome-wide CRISPR/Cas9 screening in the presence of MEK inhibitor to identify genes that are synthetically lethal with MEK inhibition in CRC models harboring KRAS mutations. Despite showing potent efficacy in BRAF-mutated melanoma, MEK inhibitors appeared to be tolerated by colorectal cancer cells due to their intrinsic compensatory signaling. Targeting the KRAS pathway is a promising but challenging approach for colorectal cancer therapy.
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